发明公开
- 专利标题： COMPOSITIONS AND METHODS FOR IMPROVED PROTEIN PRODUCTION
- 专利标题（中）： 改进的蛋白质生产的组合物和方法
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申请号： EP15760323.4申请日： 2015-08-14
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公开(公告)号： EP3180354A1公开(公告)日： 2017-06-21
- 发明人: MADRID, Susan M.
- 申请人： Danisco US Inc.
- 申请人地址： 925 Page Mill Road Palo Alto, California 94304 US
- 专利权人： Danisco US Inc.
- 当前专利权人： Danisco US Inc.
- 当前专利权人地址： 925 Page Mill Road Palo Alto, California 94304 US
- 代理机构： Kiddle, Simon John
- 优先权： US201462038095P 20140815
- 国际公布： WO2016025825 20160218
- 主分类号： C07K14/37
- IPC分类号： C07K14/37 ; C12N9/02 ; C12N15/67 ; C12N15/80 ; C12N9/30
摘要：
Aspects of the present disclosure are drawn to methods of improving the expression of secreted cuproenzymes from host cells by manipulating the expression level of one or more proteins involved in copper transport in the host cell, e.g., membrane-bound copper transporting ATPases and soluble copper transporters. The present disclosure also provides compositions containing such improved host cells as well as products derived from the improved host cells that contain one or more cuproenzymes of interest.
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