A hybrid monitoring-sleeping method of wireless sensor and the wireless sensor are provided by the present invention, during N (N= N1+N2) monitoring-sleeping period, the wireless sensor monitors with the first monitoring duration, the wake-up data packet transmitted by the data acquisitor or the mobile terminal in the N1 monitoring-sleeping periods, and the wireless sensor monitors with the second monitoring duration, the wake-up data packet transmitted by the mobile terminal in the remaining N2 monitoring-sleeping periods. The first monitoring duration is longer than the second monitoring duration, N1 is less than or equal to N2, and the N1 first monitoring duration and the N2 second monitoring duration are alternatively distributed. Compared with the single monitoring duration used in the prior art, the total monitoring duration of the N monitoring-sleeping periods is reduced, as a result, the monitoring power consumption of the wireless sensor is also reduced.