A tissue grasping device includes a first actuating member and a second actuating member that are provided at a distal end portion of a longitudinal axis member and are capable of approaching and separating each other, and a first loop portion and a second loop portion that are curved in a loop shape by a wire member. A first actuating member includes a first restricting portion that restricts an extending direction of a first end portion of the first loop portion. A second actuating member includes a second restricting portion that restricts an extending direction of a first end portion of the second loop portion. The first end portion of the first loop portion intersects an outer side surface of the first actuating member and extends to the outside of the outer side surface of the first actuating member. The first end portion of the second loop portion intersects an outer side surface of the second actuating member and extends to the outside of the outer side surface of the second actuating member.