Provided is a method of producing a composition containing a monoglyceride using a tall fatty acid as a constituent fatty acid in which crystallization at low temperature is more controlled. The method of producing a composition containing a monoglyceride using a tall fatty acid as a constituent fatty acid includes the following steps (1) and (2): (1) subjecting glycerin and the tall fatty acid to an esterification reaction in such a manner that a ratio of the number of moles of a fatty acid group to the number of moles of a glycerin group, [FA/GLY], falls within the range of from 0.1 to 2.0, followed by recovery of unreacted glycerin; and (2) subjecting glycerin including the glycerin recovered in the step (1) and the tall fatty acid to the esterification reaction.