Systems and methods of grouping image regions of an image and processing the image based on the different groups are disclosed. A system (100, 1100) is provided including a processor (114, 1110) and a memory (118, 1120) storing instructions. The instructions cause the processor to obtain (201) an image and determine (202) multiple image regions of the image. A morphological skeleton is determined (203) for each of the image regions, and distances between image regions are determined (204) based on the morphological skeletons. Multiple groups of two or more of the image regions are determined (205) based on the distances, and the image is processed (206) based on the groups.