- 专利标题: TETRAHYDRONAPHTHYRIDINE DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE
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申请号: EP15836358申请日: 2015-08-24
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公开(公告)号: EP3185865A4公开(公告)日: 2018-05-02
- 发明人: ARASAPPAN ASHOK , BUNGARD CHRISTOPHER JAMES , FRIE JESSICA L , HAN YONGXIN , HOYT SCOTT B , MANLEY PETER J , MEISSNER ROBERT S , PERKINS JAMES J , SEBHAT IYASSU K , WILKENING ROBERT R , LEAVITT KENNETH J
- 申请人: MERCK SHARP & DOHME , MERCK CANADA INC
- 专利权人: MERCK SHARP & DOHME,MERCK CANADA INC
- 当前专利权人: MERCK SHARP & DOHME,MERCK CANADA INC
- 优先权: CN2014085582 2014-08-29
- 主分类号: A61K31/4375
- IPC分类号: A61K31/4375
摘要:
The present invention provides quinoline carboxamide and quinoline carbonitrile compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, L, X1, X2, and X3, are as defined herein. The compounds of the invention, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising them, are useful as non-competitive mGluR2 antagonists, or mGluR2 negative allosteric modulators (NAMs), and may be useful in methods of treating a person in need thereof for diseases or disorders in which the mGluR2-NAM receptor plays a causative role, such as Alzheimer's disease, cognitive impairment, schizophrenia and other mood disorders, pain disorders and sleep disorders.
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