- 专利标题： ARGININE DEIMINASE WITH REDUCED CROSS-REACTIVITY TOWARD ADI - PEG 20 ANTIBODIES FOR CANCER TREATMENT
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申请号： EP15842576申请日： 2015-09-16
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公开(公告)号： EP3193913A4公开(公告)日： 2018-07-18
- 发明人: SHOWALTER RICHARD , ALMASSY ROBERT , THOMSON JAMES A , SISSON WES , SHIA WEI-JONG , CHEN LI-CHANG , LEE YANG
- 申请人： POLARIS GROUP , SHOWALTER RICHARD
- 专利权人： POLARIS GROUP,SHOWALTER RICHARD
- 当前专利权人： POLARIS GROUP,SHOWALTER RICHARD
- 优先权： US201462051182 2014-09-16
- 主分类号： A61K38/50
- IPC分类号： A61K38/50 ; A61K47/60 ; A61P35/00
摘要：
The present invention relates generally to isolated to arginine deiminase (ADI) proteins that have reduced cross-reactivity with anti-ADI-PEG 20 antibodies as compared to ADI-PEG 20, but which can have functional characteristics comparable to or better than ADI-PEG 20, compositions comprising the ADI proteins, and related methods of treating arginine-dependent diseases or related diseases such as cancer.
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