发明公开
- 专利标题： INHIBITORS OF HIF PROLYL HYDROXYLASE
- 专利标题（中）： HIF抑制剂羟丙基甲基纤维素酶
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申请号： EP15845304.3申请日： 2015-09-23
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公开(公告)号： EP3197455A1公开(公告)日： 2017-08-02
- 发明人: CAI, Jiaqiang , COLANDREA, Vincent , CRESPO, Alejandro , DEBENHAM, John , DU, Xiaoxing , GUIADEEN, Deodialsingh , LIU, Ping , LIU, Rongqiang , MADSEN-DUGGAN, Cristina, B. , MCCOY, Joshua, G. , QUAN, Weiguo , SINZ, Christopher , WANG, Liping
- 申请人： Merck Sharp & Dohme Corp. , MSD R & D (China) Co. Ltd.
- 申请人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 专利权人： Merck Sharp & Dohme Corp.,MSD R & D (China) Co. Ltd.
- 当前专利权人： Merck Sharp & Dohme Corp.,MSD R & D (China) Co. Ltd.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 代理机构： Jaap, David Robert
- 优先权： PCT/CN2014/087695 20140928
- 国际公布： WO2016049097 20160331
- 主分类号： A61K31/4704
- IPC分类号： A61K31/4704
摘要：
The present invention concerns a compound of formula I or a pharmaceutically acceptable salt thereof, which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
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