发明公开
EP3199547A1 DUAL VARIABLE REGION ANTIBODY-LIKE BINDING PROTEINS HAVING CROSS-OVER BINDING REGION ORIENTATION
审中-公开
具有交叉结合区域取向的双变量区域抗体样结合蛋白
- 专利标题： DUAL VARIABLE REGION ANTIBODY-LIKE BINDING PROTEINS HAVING CROSS-OVER BINDING REGION ORIENTATION
- 专利标题（中）： 具有交叉结合区域取向的双变量区域抗体样结合蛋白
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申请号： EP16205057.9申请日： 2012-03-28
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公开(公告)号： EP3199547A1公开(公告)日： 2017-08-02
- 发明人: Baurin, Nicolas , Beil, Christian , Corvey, Carsten , Lange, Christian , Li, Danxi , Mikol, Vincent , Steinmetz, Anke , Ercole, Rao
- 申请人： SANOFI
- 申请人地址： 54, rue La Boétie 75008 Paris FR
- 专利权人： SANOFI
- 当前专利权人： SANOFI
- 当前专利权人地址： 54, rue La Boétie 75008 Paris FR
- 代理机构： Zwicker, Jörk
- 优先权： US201161468276P 20110328; FR1160311 20111114
- 主分类号： C07K16/00
- IPC分类号： C07K16/00 ; C07K16/24 ; C07K16/28 ; C07K16/32 ; C07K16/46
摘要：
The invention provides antibody-like binding proteins comprising four polypeptide chains that form four antigen binding sites, wherein each pair of polypeptides forming an antibody-like binding protein possesses dual variable domains having a crossover orientation. The invention also provides methods for making such antigen-like binding proteins.
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