发明公开
EP3201217A1 NOVEL CYCLIC MONOMER AND DIMER PEPTIDES HAVING INTEGRIN ANTAGONIST ACTIVITY
审中-公开
具有整合拮抗剂活性的新型环状单体和二聚体肽
- 专利标题： NOVEL CYCLIC MONOMER AND DIMER PEPTIDES HAVING INTEGRIN ANTAGONIST ACTIVITY
- 专利标题（中）： 具有整合拮抗剂活性的新型环状单体和二聚体肽
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申请号： EP15846983.3申请日： 2015-10-01
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公开(公告)号： EP3201217A1公开(公告)日： 2017-08-09
- 发明人: BHANDARI, Ashok , PATEL, Dinesh V. , ZEMEDE, Genet
- 申请人： Protagonist Therapeutics Inc.
- 申请人地址： 521 Cottonwood Drive Suite A Milpitas, California 95035 US
- 专利权人： Protagonist Therapeutics Inc.
- 当前专利权人： Protagonist Therapeutics Inc.
- 当前专利权人地址： 521 Cottonwood Drive Suite A Milpitas, California 95035 US
- 代理机构： Schiweck, Weinzierl & Koch Patentanwälte Partnerschaft mbB
- 优先权： US201462058525P 20141001; US201462058563P 20141001
- 国际公布： WO2016054445 20160407
- 主分类号： C07K7/18
- IPC分类号： C07K7/18 ; A61K38/00
摘要：
The invention relates to C to N cyclized (C-N cyclic) monomer and dimer peptide molecules, as well as peptide dimers which are connected by linker moieties at the N terminus and the C terminus of each peptide subunit, which inhibit binding of α4β7 to the mucosal addressin cell adhesion molecule (MAdCAM) in vivo, and show high selectivity against α4β1 binding.
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