发明公开
EP3204490A1 ENDOGENOUS RETROVIRUS TRANSCRIPTION AS A MARKER FOR PRIMATE NAÏVE PLURIPOTENT STEM CELLS
审中-公开
内源性逆转录病毒转录作为原始不育多功能干细胞的标记物
- 专利标题： ENDOGENOUS RETROVIRUS TRANSCRIPTION AS A MARKER FOR PRIMATE NAÏVE PLURIPOTENT STEM CELLS
- 专利标题（中）： 内源性逆转录病毒转录作为原始不育多功能干细胞的标记物
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申请号： EP15775703.0申请日： 2015-10-07
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公开(公告)号： EP3204490A1公开(公告)日： 2017-08-16
- 发明人: WANG, Jichang , IZSVÁK, Zsuzsanna , HURST, Laurence D.
- 申请人： Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft , University Of Bath
- 申请人地址： Robert-Rössle-Strasse 10 13125 Berlin DE
- 专利权人： Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft,University Of Bath
- 当前专利权人： Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft,University Of Bath
- 当前专利权人地址： Robert-Rössle-Strasse 10 13125 Berlin DE
- 代理机构： Hertin und Partner Rechts- und Patentanwälte PartG mbB
- 优先权： DE102014114558 20141007
- 国际公布： WO2016055519 20160414
- 主分类号： C12N5/0735
- IPC分类号： C12N5/0735 ; C12N5/074
摘要：
One or more type 7 long terminal repeat (LTR7) nucleic acid sequences of type H human endogenous retroviruses (HERVH) (“LTR7/HERVH nucleic acid sequences”) can be used for identifying primate naïve pluripotent stem cells. LTR7/HERVH-associated transcription can be used as a marker for primate naive pluripotent stem cells. A reporter construct that includes LTR7/HERVH nucleic acid sequences can be used for optimizing culture conditions for naïve primate pluripotent stem cells. A cell growth medium can be used for cultivation of primate naive pluripotent stem cells, which can exhibit elevated levels of LTR7/HERVH-associated transcription in comparison to control cells.
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