发明公开
EP3213770A1 IMMUNE REGULATORY OLIGONUCLEOTIDE (IRO) COMPOUNDS TO MODULATE TOLL-LIKE RECEPTOR BASED IMMUNE RESPONSE
审中-公开
免疫调节性寡核苷酸（IRO）化合物调节TOLL样受体免疫反应
- 专利标题： IMMUNE REGULATORY OLIGONUCLEOTIDE (IRO) COMPOUNDS TO MODULATE TOLL-LIKE RECEPTOR BASED IMMUNE RESPONSE
- 专利标题（中）： 免疫调节性寡核苷酸（IRO）化合物调节TOLL样受体免疫反应
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申请号： EP17166068.1申请日： 2011-11-18
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公开(公告)号： EP3213770A1公开(公告)日： 2017-09-06
- 发明人: KANDIMALLA, Ekambar, R. , WANG, Daqing , NOWAK, Ireneusz , AGRAWAL, Sudhir
- 申请人： Idera Pharmaceuticals, Inc.
- 申请人地址： 167 Sidney Street Cambridge, MA 02139 US
- 专利权人： Idera Pharmaceuticals, Inc.
- 当前专利权人： Idera Pharmaceuticals, Inc.
- 当前专利权人地址： 167 Sidney Street Cambridge, MA 02139 US
- 代理机构： Böhmer, Thomas
- 优先权： US415494P 20101119; US201161511709P 20110726
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C07H21/04 ; C12N15/113
摘要：
The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.
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