- 专利标题： USE OF CHIMERIC ANTIGEN RECEPTOR-MODIFIED T CELLS TO TREAT CANCER
-
申请号： EP17153799.6申请日： 2011-12-09
-
公开(公告)号： EP3214091B1公开(公告)日： 2018-10-03
- 发明人: JUNE, Carl H. , LEVINE, Bruce L. , PORTER, David L. , KALOS, Michael D. , MILONE, Michael C.
- 申请人： The Trustees of The University of Pennsylvania
- 申请人地址： Center of Technology Transfer 3160 Chestnut Street, Suite 200 Philadelphia, PA 19104-6283 US
- 专利权人： The Trustees of The University of Pennsylvania
- 当前专利权人： The Trustees of The University of Pennsylvania
- 当前专利权人地址： Center of Technology Transfer 3160 Chestnut Street, Suite 200 Philadelphia, PA 19104-6283 US
- 代理机构： Bassil, Nicholas Charles
- 优先权： US421470P 20101209; US201161502649P 20110629
- 主分类号： C07H21/04
- IPC分类号： C07H21/04 ; A61K39/00
摘要：
The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain.
公开/授权文献
信息查询
