发明公开
EP3217968A1 SUBSTITUTED AROMATIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR TISSUE SELF-REPAIR AND REGENERATION
审中-公开
用于组织自我修复和再生的取代芳香族化合物和药物组合物
- 专利标题： SUBSTITUTED AROMATIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR TISSUE SELF-REPAIR AND REGENERATION
- 专利标题（中）： 用于组织自我修复和再生的取代芳香族化合物和药物组合物
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申请号： EP15859768.2申请日： 2015-11-12
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公开(公告)号： EP3217968A1公开(公告)日： 2017-09-20
- 发明人: GAGNON, Lyne , LAURIN, Pierre
- 申请人： PROMETIC PHARMA SMT LIMITED
- 申请人地址： Horizon Park Barton Road Comberton Cambridge CB23 7AJ GB
- 专利权人： PROMETIC PHARMA SMT LIMITED
- 当前专利权人： PROMETIC PHARMA SMT LIMITED
- 当前专利权人地址： Horizon Park Barton Road Comberton Cambridge CB23 7AJ GB
- 代理机构： Hutter, Anton
- 优先权： US201462078704P 20141112
- 国际公布： WO2016074068 20160519
- 主分类号： A61K31/192
- IPC分类号： A61K31/192 ; A61K8/36 ; A61P17/02 ; A61Q19/08 ; C07C57/30 ; C07C57/32 ; C07C57/58 ; C07C59/52 ; C07C59/84
摘要：
Described herein are compounds of Formula I, or pharmaceutically acceptable salts thereof, or combinations thereof, as well as uses thereof. Such uses include promoting tissue self-repair or tissue regeneration of an organ, stimulating the generation of tissue growth, modulating (e.g. increasing) the level of a tissue-repair marker, treating physical injury in an organ, tissue, or cell, promoting wound healing as well as anti-aging applications. Corresponding compositions, methods and uses are also described. Formula I wherein A is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)-(CH2)n-CH3 wherein n is 3 or 4; R1 is H, F of OH; R2 is H, F, OH, C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)-(CH2)n-CH3 wherein n is 3 or 4; R3 is H, F, OH, or CH2Ph; R4 is H, F or OH; Q is 1) (CH2),C(0)OH wherein m is 1 or 2 2) CH(CH3)C(0)OH, 3) C(CH3)2C(0)OH, 4) CH(F)-C(0)OH, 5) CF2-C(0)OH or 6) C(0)-C(0)OH.
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