Methods for driving electro-optic displays to reduce visible artifacts include (a) applying a first drive scheme to a minor proportion of the display pixels and a second drive scheme to other pixels, the pixels using the first drive scheme varying at each transition; (b) using different drive schemes on different pixel groups so that pixels in differing groups undergoing the same transition use different waveforms; (c) applying a balanced pulse pair or a top-off pulse to a pixel undergoing a white-to-white transition and lying adjacent a pixel undergoing a visible transition; (d) driving extra pixels where the boundary between driven and undriven areas falls along a straight line; and (e) driving a display with both DC balanced and DC imbalanced drive schemes, maintaining an impulse bank value for the DC imbalance and modifying transitions to reduce the impulse bank value.