发明公开
- 专利标题： CLONAL HAEMATOPOIESIS
- 专利标题（中）： 克隆人HAEMATOPOIESIS
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申请号： EP15810708.6申请日： 2015-11-23
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公开(公告)号： EP3224380A1公开(公告)日： 2017-10-04
- 发明人: MCCARROLL, Steven Andrew , GENOVESE, Giulio
- 申请人： The Broad Institute Inc. , President and Fellows of Harvard College
- 申请人地址： 415 Main Street Cambridge, MA 02142 US
- 专利权人： The Broad Institute Inc.,President and Fellows of Harvard College
- 当前专利权人： The Broad Institute Inc.,President and Fellows of Harvard College
- 当前专利权人地址： 415 Main Street Cambridge, MA 02142 US
- 代理机构： De Clercq & Partners
- 优先权： US201462084112P 20141125
- 国际公布： WO2016085876 20160602
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68
摘要：
The present invention relates to clonal expansion of somatic cells in subjects, and acquired selective advantage of cell clones during the lifetime of a subject. In particular, the invention relates to methods for predicting the development of cancer based on the observation of specific genetic mutations in somatic cell clones, as well as to methods for treating or preventing cancer in a subject, in which clonal expansion of cells comprising specific modifications is observed.
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