发明公开
EP3226900A1 IDENTIFICATION OF VSIG8 AS THE PUTATIVE VISTA RECEPTOR AND ITS USE THEREOF TO PRODUCE VISTA/VSIG8 MODULATORS
审中-公开
鉴定VSIG8作为对照VISTA受体及其用于制备VISTA / VSIG8调节剂的用途
- 专利标题： IDENTIFICATION OF VSIG8 AS THE PUTATIVE VISTA RECEPTOR AND ITS USE THEREOF TO PRODUCE VISTA/VSIG8 MODULATORS
- 专利标题（中）： 鉴定VSIG8作为对照VISTA受体及其用于制备VISTA / VSIG8调节剂的用途
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申请号： EP15865129.9申请日： 2015-12-05
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公开(公告)号： EP3226900A1公开(公告)日： 2017-10-11
- 发明人: MOLLOY, Michael , GUO, Yalin , ROTHSTEIN, Jay , ROSENZWEIG, Michael
- 申请人： Immunext, Inc.
- 申请人地址： 16 Cavendish Court Lebanon, New Hampshire 03766 US
- 专利权人： Immunext, Inc.
- 当前专利权人： Immunext, Inc.
- 当前专利权人地址： 16 Cavendish Court Lebanon, New Hampshire 03766 US
- 代理机构： Stephens, Clare Jean
- 优先权： US201462088058P 20141205
- 国际公布： WO2016090347 20160609
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/46 ; A61K38/16
摘要：
The receptor for VISTA is identified (VSIG8) as well as the use of this receptor in the identification or synthesis of agonist or antagonist compounds, preferably antibodies, polypeptides and fusion proteins which agonize or antagonize the effects of VSIG8 and/or VISTA and/or the VSIG8/VISTA binding interaction. These antagonists may be used to suppress VISTA's suppressive effects on T cell immunity, and more particularly used in the treatment of cancer, or infectious disease. These agonist compounds may be used to potentiate or enhance VISTA's suppressive effects on T cell immunity and thereby suppress T cell immunity, such as in the treatment of autoimmunity, allergy or inflammatory conditions. Screening assays for identifying these agonists and antagonist compounds are also provided.
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