发明公开
- 专利标题： PROTEIN-POLYMER-DRUG CONJUGATES
- 专利标题（中）： 蛋白质 - 聚合物 - 药物共轭物
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申请号： EP17159707.3申请日： 2012-06-11
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公开(公告)号： EP3228325A1公开(公告)日： 2017-10-11
- 发明人: YURKOVETSKIY, Aleksandr , YIN, Mao , LOWINGER, Timothy B , THOMAS, Joshua D , HAMMOND, Charles E , STEVENSON, Cheri A , BODYAK, Natalya D , CONLON, Patrick R , GUMEROV, Dmitry R
- 申请人： Mersana Therapeutics, Inc.
- 申请人地址： 840 Memorial Drive Cambridge, MA 02139 US
- 专利权人： Mersana Therapeutics, Inc.
- 当前专利权人： Mersana Therapeutics, Inc.
- 当前专利权人地址： 840 Memorial Drive Cambridge, MA 02139 US
- 代理机构： Cooley (UK) LLP
- 优先权： US201161495771P 20110610; US201161501000P 20110624; US201161513234P 20110729; US201161566935P 20111205; US201261605618P 20120301; US201261618499P 20120330
- 主分类号： A61K47/59
- IPC分类号： A61K47/59 ; A61K47/68 ; A61K47/64 ; A61P35/00
摘要：
A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier comprising poly(1-hydroxymethylethylene hydroxymethyl-formal) (PHF) substituted with one or more -L D -D, the protein based recognition-molecule being connected to the polymeric carrier by L p . Each occurrence of D is independently a therapeutic agent having a molecular weight ≤ 5 kDa, L D and L p are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds comprising PHF useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates of their compositions.
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