发明公开
- 专利标题： CRISPR-BASED COMPOSITIONS AND METHODS OF USE
- 专利标题（中）： 基于CRISPR的组合物和使用方法
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申请号： EP15828610.4申请日： 2015-12-18
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公开(公告)号： EP3234133A2公开(公告)日： 2017-10-25
- 发明人: COLLINGWOOD, Michael, Allen , JACOBI, Ashley, Mae , RETTIG, Garrett, Richard , SCHUBERT, Mollie, Sue , BEHLKE, Mark, Aaron
- 申请人： Integrated DNA Technologies, Inc.
- 申请人地址： 818 McCormick Boulevard Skokie, IL 60076 US
- 专利权人： Integrated DNA Technologies, Inc.
- 当前专利权人： Integrated DNA Technologies, Inc.
- 当前专利权人地址： 818 McCormick Boulevard Skokie, IL 60076 US
- 代理机构： Modiano, Micaela Nadia
- 优先权： US201462093588P 20141218; US201562239546P 20151009
- 国际公布： WO2016100951 20160623
- 主分类号： C12N15/11
- IPC分类号： C12N15/11
摘要：
This invention pertains to modified compositions for use in CRISPR systems, and their methods of use. In particular, length-modified and chemically-modified forms of crRNA and tracrRNA are described for use as a reconstituted guide RNA for interaction with Cas9 of CRIPSR systems. The resultant length-modified and chemically-modified forms of crRNA and tracrRNA are economical to produce and can be tailored to have unique properties relevant to their biochemical and biological activity in the context of the CRIPSR Cas9 endonuclease system.
公开/授权文献
- EP3234133B1 CRISPR-BASED COMPOSITIONS AND METHODS OF USE 公开/授权日：2020-11-11
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