发明公开
- 专利标题: TARGETED RNA EDITING
- 专利标题(中): 靶向RNA编辑
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申请号: EP15813826.3申请日: 2015-12-17
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公开(公告)号: EP3234134A1公开(公告)日: 2017-10-25
- 发明人: KLEIN, Bart , PLATENBURG, Gerard Johannes
- 申请人: ProQR Therapeutics II B.V.
- 申请人地址: Zernikedreef 9 2333 CK Leiden NL
- 专利权人: ProQR Therapeutics II B.V.
- 当前专利权人: ProQR Therapeutics II B.V.
- 当前专利权人地址: Zernikedreef 9 2333 CK Leiden NL
- 代理机构: Spinner, David Richard
- 优先权: GB201422511 20141217; GB201512467 20150716; GB201512595 20150717; GB201521987 20151214
- 国际公布: WO2016097212 20160623
- 主分类号: C12N15/113
- IPC分类号: C12N15/113
摘要:
RNA editing is achieved using oligonucleotide constructs comprising (i) a targeting portion specific for a target nucleic acid sequence to be edited and (ii) a recruiting portion capable of binding and recruiting a nucleic acid editing entity naturally present in the cell. The nucleic acid editing entity, such as ADAR, is redirected to a preselected target site by means of the targeting portion, thereby promoting editing of preselected nucleotide residues in a region of the target RNA which corresponds to the targeting portion.
公开/授权文献
- EP3234134B1 TARGETED RNA EDITING 公开/授权日:2020-05-27
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