发明公开
EP3237406A1 5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS
审中-公开
5 - [（哌嗪-1-基）-3-氧代 - 丙基] - 咪唑并吡啶-2,4-二酮衍生物作为ADAMTS抑制剂治疗骨关节炎的药物
- 专利标题： 5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS
- 专利标题（中）： 5 - [（哌嗪-1-基）-3-氧代 - 丙基] - 咪唑并吡啶-2,4-二酮衍生物作为ADAMTS抑制剂治疗骨关节炎的药物
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申请号： EP15813831.3申请日： 2015-12-18
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公开(公告)号： EP3237406A1公开(公告)日： 2017-11-01
- 发明人: BREBION, Franck, Laurent , ALVEY, Luke, Jonathan , AMANTINI, David , DEPREZ, Pierre, Marc, Marie, Joseph , GOSMINI, Romain, Luc, Marie , JARY, Helène, Marie , PEIXOTO, Christophe , VARIN, Marie, Laurence, Claire , DE CEUNINCK, Frédéric, André , POP-BOTEZ, Iuliana, Ecaterina
- 申请人： Galapagos NV , Les Laboratoires Servier
- 申请人地址： Generaal De Wittelaan L11/A3 2800 Mechelen BE
- 专利权人： Galapagos NV,Les Laboratoires Servier
- 当前专利权人： Galapagos NV,Les Laboratoires Servier
- 当前专利权人地址： Generaal De Wittelaan L11/A3 2800 Mechelen BE
- 代理机构： Bar, Grégory
- 优先权： EP14307129 20141222
- 国际公布： WO2016102347 20160630
- 主分类号： C07D403/06
- IPC分类号： C07D403/06 ; A61K31/496 ; A61P19/02 ; A61P19/04
摘要：
The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory conditions, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis by administering a compound of the invention.
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