Systems and methods for delivering interrupts to user-level applications. An example processing system comprises: a memory configured to store a plurality of user-level APIC data structures and a plurality of user-level interrupt handler address data structures corresponding to a plurality of user-level applications being executed by the processing system; and a processing core configured, responsive to receiving a notification of a user-level interrupt, to: set a pending interrupt bit flag having a position defined by an identifier of the user-level interrupt in a user-level APIC data structure associated with a user-level application that is currently being executed by the processing core, and invoke a user-level interrupt handler identified by a user-level interrupt handler address data structure associated with the user-level application, for a pending user-level interrupt having a highest priority among one or more pending user-level interrupts identified by the user-level APIC data structure.