发明公开
EP3240771A1 PROCESS FOR THE PREPARATION OF OSPEMIFENE AND FISPEMIFENE
审中-公开
OSPEMIFENE和FISPEMIFENE的制备方法
- 专利标题： PROCESS FOR THE PREPARATION OF OSPEMIFENE AND FISPEMIFENE
- 专利标题（中）： OSPEMIFENE和FISPEMIFENE的制备方法
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申请号： EP15830869.2申请日： 2015-12-28
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公开(公告)号： EP3240771A1公开(公告)日： 2017-11-08
- 发明人: CRISTIANO, Tania , ALPEGIANI, Marco
- 申请人： OLON S.p.A.
- 申请人地址： Strada Rivoltana km. 6/7 20090 Rodano (MI) IT
- 专利权人： OLON S.p.A.
- 当前专利权人： OLON S.p.A.
- 当前专利权人地址： Strada Rivoltana km. 6/7 20090 Rodano (MI) IT
- 代理机构： Bianchetti Bracco Minoja S.r.l.
- 优先权： ITMI20142267 20141229
- 国际公布： WO2016108172 20160707
- 主分类号： C07C41/16
- IPC分类号： C07C41/16
摘要：
Disclosed is a process for the synthesis of the active ingredients ospemifene and fispemifene which comprises reacting phenol 4 with an alkylating agent X- CH2CH2-Y of formula 7, wherein X is a leaving group and Y is the -(OCH2CH2)nOH group wherein n is zero or 1; or X and Y, taken together, represent an oxygen atom; to give ospemifene or fispemifene of formula 8.
公开/授权文献
- EP3240771B1 PROCESS FOR THE PREPARATION OF OSPEMIFENE AND FISPEMIFENE 公开/授权日：2019-02-20
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