- 专利标题： PHENYL C-GLUCOSIDE DERIVATIVE CONTAINING DEOXYGLUCOSE STRUCTURE, PREPARATION METHOD AND USES THEREOF
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申请号： EP17176326.1申请日： 2013-12-05
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公开(公告)号： EP3246324A2公开(公告)日： 2017-11-22
- 发明人: ZHAO, Guilong , WANG, Yuli , LIU, Bingni , XIE, Yafei , LIU, Yuqiang , LIU, Peng , WU, Jiang , HOU, Jiajia , WEI, Wei , DU, Wen , XU, Weiren , TANG, Lida , ZOU, Meixiang
- 申请人： Tianjin Institute Of Pharmaceutical Research
- 申请人地址： NO.308 An-shan West Road, Nankai District Tianjin 300193 CN
- 专利权人： Tianjin Institute Of Pharmaceutical Research
- 当前专利权人： Tianjin Institute Of Pharmaceutical Research
- 当前专利权人地址： NO.308 An-shan West Road, Nankai District Tianjin 300193 CN
- 代理机构： Herrmann, Uwe
- 优先权： CN201210553525 20121217; CN201310083945 20130315; CN201310109527 20130401; CN201310213608 20130531; CN201310237558 20130617
- 主分类号： C07D309/10
- IPC分类号： C07D309/10 ; C07D409/10 ; C07D407/12 ; C07D493/10 ; C07D493/08 ; C07D335/02 ; C07H19/01 ; C07H9/04 ; C07H1/00 ; A61K31/351 ; A61K31/381 ; A61K31/7048 ; A61K31/382 ; A61P3/10
摘要：
The present invention provides a phenyl C-glucoside derivative containing a deoxyglucose structure as represented by formula I, preparation method thereof, a pharmaceutical composition comprising the same, and uses thereof in the preparation of medicaments for treating diabetes, wherein substituents R 1 -R 7 are as defined in the specification. The present invention also provides a method for synthesizing the phenyl C-glucoside derivative containing a deoxyglucose structure and an intermediate product. The method has advantages of being simple to manage and of low cost, which is suitable for large-scale industrial production. The present invention further provides a cocrystal of (1S)-1-[4-chloro-3-(4-ethoxybenzyl)phenyl]-1,6-dideoxy-D-glucose and L-proline, and preparation method and uses thereof.
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