发明公开
- 专利标题： RESORCINOL DERIVATIVE AS HSP90 INHIBITOR
- 专利标题（中）： 间苯二酚衍生物作为HSP90抑制剂
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申请号： EP16739808.0申请日： 2016-01-22
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公开(公告)号： EP3248968A1公开(公告)日： 2017-11-29
- 发明人: CHEN, Shuhui , DING, Charles Z. , YAN, Xiaobing , HUANG, Wei , HU, Guoping , LI, Jian , ZHANG, Xiquan , YANG, Ling , XU, Hongjiang
- 申请人： Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
- 申请人地址： No. 369 Yuzhou South Road, Haizhou District Lianyungang Jiangsu 222062 CN
- 专利权人： Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
- 当前专利权人： Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
- 当前专利权人地址： No. 369 Yuzhou South Road, Haizhou District Lianyungang Jiangsu 222062 CN
- 代理机构： Gulde & Partner
- 优先权： CN201510033985 20150122; CN201610019396 20160112; CN201610033498 20160119
- 国际公布： WO2016116061 20160728
- 主分类号： C07D413/04
- IPC分类号： C07D413/04 ; C07D487/08 ; C07D495/04 ; C07D513/04 ; C07D471/04 ; C07D417/04 ; C07D413/14 ; A61K31/4725 ; A61K31/422 ; A61K31/4365 ; A61K31/437
摘要：
The present invention relates to a compound represented by formula (I) of a resorcinol derivative as an HSP90 inhibitor or pharmaceutically accepted salts thereof. The compound in the present invention has the activity of inhibiting heat shock protein HSP90. Therefore, the compound in the present invention is used to treat proliferative diseases such as cancer and neurodegenerative diseases. The present invention further provides the compounds and preparation methods for pharmaceutical compositions comprising the compounds, a method for treating diseases, and pharmaceutical compositions comprising the compounds.
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