发明公开
EP3249052A1 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE PCSK9 GENE
审中-公开
抑制PCSK9基因表达的组合物和方法
- 专利标题： COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE PCSK9 GENE
- 专利标题（中）： 抑制PCSK9基因表达的组合物和方法
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申请号： EP17162101.4申请日： 2007-05-10
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公开(公告)号： EP3249052A1公开(公告)日： 2017-11-29
- 发明人: TAN, Pamela , BRAMLAGE, Birgit , FRANK-KAMENETSKY, Maria , FITZGERALD, Kevin , AKINC, Akin , KOTELIANSKI, Victor E.
- 申请人： Alnylam Pharmaceuticals, Inc.
- 申请人地址： 300 Third Street Cambridge, MA 02142 US
- 专利权人： Alnylam Pharmaceuticals, Inc.
- 当前专利权人： Alnylam Pharmaceuticals, Inc.
- 当前专利权人地址： 300 Third Street Cambridge, MA 02142 US
- 代理机构： Vossius & Partner Patentanwälte Rechtsanwälte mbB
- 优先权： US799458P 20060511; US817203P 20060627; US840089P 20060825; US829914P 20061018; US901134P 20070213
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; A01N43/04 ; C07H21/04 ; A61K31/07 ; C12N15/113
摘要：
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the PCSK9 gene (PCSK9 gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the PCSK9 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by PCSK9 gene expression and the expression of the PCSK9 gene using the pharmaceutical composition.
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