发明公开
EP3250684A1 RNA VIRUS ATTENUATION BY ALTERATION OF MUTATIONAL ROBUSTNESS AND SEQUENCE SPACE
审中-公开
基因突变和序列空间改变RNA病毒衰减
- 专利标题： RNA VIRUS ATTENUATION BY ALTERATION OF MUTATIONAL ROBUSTNESS AND SEQUENCE SPACE
- 专利标题（中）： 基因突变和序列空间改变RNA病毒衰减
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申请号： EP16701946.2申请日： 2016-01-28
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公开(公告)号： EP3250684A1公开(公告)日： 2017-12-06
- 发明人: VIGNUZZI, Marco , BARBEZANGE, Cyril , MORATORIO,Gonzalo
- 申请人： Institut Pasteur
- 申请人地址： 25-28 Rue du Docteur Roux 75724 Paris Cedex 15 FR
- 专利权人： Institut Pasteur
- 当前专利权人： Institut Pasteur
- 当前专利权人地址： 25-28 Rue du Docteur Roux 75724 Paris Cedex 15 FR
- 代理机构： Desaix, Anne
- 优先权： EP15305098 20150128
- 国际公布： WO2016120412 20160804
- 主分类号： C12N7/00
- IPC分类号： C12N7/00 ; A61K39/12 ; A61K39/00
摘要：
The application generally relates to the attenuation of a RNA virus or of a clone thereof and involves the alteration of sequence space, more particularly the reduction, of mutational robustness of said RNA virus or clone. The means of the application are more particularly dedicated to the attenuation of an infectious RNA virus or clone, for the production of immunogenic composition or vaccine. More particularly, the means of the application involve the replacement of codon(s) by different codon(s), which is(are) selected to differ by only one nucleotide from a codon STOP, more particularly by different but synonymous codon(s), which is(are) selected to differ by only one nucleotide from a codon STOP.
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