发明公开
EP3253778A1 ANTIBODIES COMPRISING AN ION CONCENTRATION DEPENDENT ANTIGEN-BINDING DOMAIN, FC REGION VARIANTS, IL-8-BINDING ANTIBODIES, AND USES THEROF
审中-公开
包含离子浓度依赖性抗原结合域，FC区变体，IL-8结合抗体的抗体及其用途
- 专利标题： ANTIBODIES COMPRISING AN ION CONCENTRATION DEPENDENT ANTIGEN-BINDING DOMAIN, FC REGION VARIANTS, IL-8-BINDING ANTIBODIES, AND USES THEROF
- 专利标题（中）： 包含离子浓度依赖性抗原结合域，FC区变体，IL-8结合抗体的抗体及其用途
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申请号： EP16705307.3申请日： 2016-02-04
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公开(公告)号： EP3253778A1公开(公告)日： 2017-12-13
- 发明人: IGAWA, Tomoyuki , MAEDA, Atsuhiko , HARAYA, Kenta , TACHIBANA, Tatsuhiko , IWAYANAGI, Yuki , HORI, Yuji
- 申请人： Chugai Seiyaku Kabushiki Kaisha
- 申请人地址： 5-1, Ukima 5-chome Kita-ku Tokyo 115-8543 JP
- 专利权人： Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人： Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人地址： 5-1, Ukima 5-chome Kita-ku Tokyo 115-8543 JP
- 代理机构： Vossius & Partner Patentanwälte Rechtsanwälte mbB
- 优先权： JP2015021371 20150205; JP2015185254 20150918
- 国际公布： WO2016125495 20160811
- 主分类号： C07K14/235
- IPC分类号： C07K14/235 ; C07K16/00
摘要：
One nonexclusive aspect provides molecules further improved from antibodies that can bind to antigens in an ion concentration-dependent manner. An alternative nonexclusive aspect provides safe and more advantageous Fc region variants that have decreased binding to pre-existing ADA. An alternative nonexclusive aspect provides novel IL-8 antibodies that are superior as pharmaceuticals.
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