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EP3261440A1 METHODS AND COMPOSITIONS FOR TREATING GENETIC EYE DISEASES 审中-公开
治疗遗传性眼病的方法和组合物

METHODS AND COMPOSITIONS FOR TREATING GENETIC EYE DISEASES
摘要:
The present disclosure provides targeting peptides and vectors containing a sequence that encodes targetting peptides that deliver agents, to the eye. The present inventors have discovered peptides that function to target agents, such as viral vectors, to ocular cells. The present disclosure describes a method to utilize these novel peptides to direct, for example, viral capsids to the cell type of interest. In this instance, ocular cells (such as retinal cells) are targeted by the identified peptides. Vectors harboring capsid proteins modified to include such peptides can be used to provide therapeutic agents to the eye.
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