发明公开
- 专利标题: METHODS AND COMPOSITIONS FOR TREATING GENETIC EYE DISEASES
- 专利标题(中): 治疗遗传性眼病的方法和组合物
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申请号: EP16753229.0申请日: 2016-02-22
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公开(公告)号: EP3261440A1公开(公告)日: 2018-01-03
- 发明人: DAVIDSON, Beverly, L. , CHEN, Yong Hong , AURICCHIO, Alberto
- 申请人: University of Iowa Research Foundation , Fondazione Telethon
- 申请人地址: 112 N. Capitol Street 6 Gilmore Hall Iowa City, Iowa 52242-5500 US
- 专利权人: University of Iowa Research Foundation,Fondazione Telethon
- 当前专利权人: University of Iowa Research Foundation,Fondazione Telethon
- 当前专利权人地址: 112 N. Capitol Street 6 Gilmore Hall Iowa City, Iowa 52242-5500 US
- 代理机构: PATERIS Patentanwälte PartmbB
- 优先权: US201562118934P 20150220
- 国际公布: WO2016134375 20160825
- 主分类号: A01N43/04
- IPC分类号: A01N43/04 ; A01N63/00 ; A01N65/00 ; A61K48/00 ; C12N15/63 ; C12N15/85
摘要:
The present disclosure provides targeting peptides and vectors containing a sequence that encodes targetting peptides that deliver agents, to the eye. The present inventors have discovered peptides that function to target agents, such as viral vectors, to ocular cells. The present disclosure describes a method to utilize these novel peptides to direct, for example, viral capsids to the cell type of interest. In this instance, ocular cells (such as retinal cells) are targeted by the identified peptides. Vectors harboring capsid proteins modified to include such peptides can be used to provide therapeutic agents to the eye.
公开/授权文献
- EP3261440B1 METHODS AND COMPOSITIONS FOR TREATING GENETIC EYE DISEASES 公开/授权日:2022-04-06
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