发明公开
- 专利标题： LYOSOMAL TARGETING PEPTIDES AND USES THEREOF
- 专利标题（中）： LYOSOMAL靶向肽及其用途
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申请号： EP17182845.2申请日： 2009-05-07
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公开(公告)号： EP3272773A1公开(公告)日： 2018-01-24
- 发明人: LEBOWITZ, Jonathan , MAGA, John
- 申请人： BioMarin Pharmaceutical Inc.
- 申请人地址： 105 Digital Drive Novato, CA 94949 US
- 专利权人： BioMarin Pharmaceutical Inc.
- 当前专利权人： BioMarin Pharmaceutical Inc.
- 当前专利权人地址： 105 Digital Drive Novato, CA 94949 US
- 代理机构： Care, Alison
- 优先权： US51336P 20080507; US144106P 20090112
- 主分类号： C07K19/00
- IPC分类号： C07K19/00 ; C07K14/475
摘要：
The present invention provides further improved compositions and methods for efficient lysosomal targeting based on the GILT technology. Among other things, the present invention provides methods and compositions for targeting lysosomal enzymes to lysosomes using furin-resistant lysosomal targeting peptides. The present invention also provides methods and compositions for targeting lysosomal enzymes to lysosomes using a lysosomal targeting peptide that has reduced or diminished binding affinity for the insulin receptor.
公开/授权文献
- EP3272773B8 LYSOSOMAL TARGETING PEPTIDES AND USES THEREOF 公开/授权日：2020-11-18
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