发明公开
EP3288943A1 PYRROLO[2,3-D]PYRIMIDINYL, PYRROLO[2,3-B]PYRAZINYL, PYRROLO[2,3-B]PYRIDINYL ACRYLAMIDES AND EPOXIDES THEREOF
审中-公开
吡咯并[2,3-D]嘧啶亚胺，吡咯并[2,3-B]吡嗪亚胺，吡咯并[2,3-B]吡啶亚基丙烯酰胺及其环氧化物
- 专利标题： PYRROLO[2,3-D]PYRIMIDINYL, PYRROLO[2,3-B]PYRAZINYL, PYRROLO[2,3-B]PYRIDINYL ACRYLAMIDES AND EPOXIDES THEREOF
- 专利标题（中）： 吡咯并[2,3-D]嘧啶亚胺，吡咯并[2,3-B]吡嗪亚胺，吡咯并[2,3-B]吡啶亚基丙烯酰胺及其环氧化物
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申请号： EP16719917.3申请日： 2016-04-19
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公开(公告)号： EP3288943A1公开(公告)日： 2018-03-07
- 发明人: THORARENSEN, Atli , BROWN, Matthew Frank , CASIMIRO-GARCIA,Agustin , CHE, Ye , FLANAGAN, Mark Edward , GILBERT, Adam Matthew , HAYWARD, Matthew Merrill , TELLIEZ, Jean-Baptiste , UNWALLA, Rayomand Jal , TRUJILLO, John I. , LIANG, Sidney Xi
- 申请人： Pfizer Inc.
- 申请人地址： 235 East 42nd Street New York, NY 10017 US
- 专利权人： Pfizer Inc.
- 当前专利权人： Pfizer Inc.
- 当前专利权人地址： 235 East 42nd Street New York, NY 10017 US
- 代理机构： Pfizer
- 优先权： US201562155824P 20150501
- 国际公布： WO2016178110 20161110
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; A61K31/395 ; A61P35/00
摘要：
The present invention provides pharmaceutically active pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3- b]pyrazinyl,and pyrrolo[2,3-b]pyridinyl acrylamides, epoxides,and analogues thereof. Such compounds are useful for inhibiting Janus Kinase (JAK). This invention also is directed to compositions comprising methods for making such compounds, and methods for treating and preventing conditions mediated by JAK.
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