- 专利标题： IN VIVO PRODUCTION OF LONG DOUBLE STRANDED RNA UTILIZING VLPS
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申请号： EP16793331申请日： 2016-05-09
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公开(公告)号： EP3294276A1公开(公告)日： 2018-03-21
- 发明人: ARHANCET JUAN PEDRO HUMBERTO , MCLAUGHLIN PATRICK D
- 申请人： APSE LLC
- 专利权人： APSE LLC
- 当前专利权人： APSE LLC
- 优先权： US201562160329 2015-05-12
- 主分类号： A61K9/50
- IPC分类号： A61K9/50 ; C12N7/01 ; C12N15/11
摘要：
Methods and compositions for producing, isolating and purifying virus-like particles (VLPs) containing long sense and antisense RNA molecules, including RNA molecules predicted to fold into double-stranded regions longer than the inner diameter of the VLP capsids are disclosed.
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