发明公开
- 专利标题： TRIMALEIMIDE LINKERS AND USES THEREOF
- 专利标题（中）： TRIMALEIMIDE链接器及其用途
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申请号： EP16802451.1申请日： 2016-05-17
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公开(公告)号： EP3302570A1公开(公告)日： 2018-04-11
- 发明人: HAN, Nianhe , AN, Deqiang , ZENG, Di , WANG, Baoxiang , YANG, Hang , JIAN, Li , YANG, Chun
- 申请人： Newbio Therapeutics, Inc.
- 申请人地址： Suite 101, Building 9, 1011 Halei Road, Pudong District, Shanghai 201203 CN
- 专利权人： Newbio Therapeutics, Inc.
- 当前专利权人： Newbio Therapeutics, Inc.
- 当前专利权人地址： Suite 101, Building 9, 1011 Halei Road, Pudong District, Shanghai 201203 CN
- 代理机构： V.O.
- 优先权： CN201510289369 20150529
- 国际公布： WO2016192528 20161208
- 主分类号： A61K47/48
- IPC分类号： A61K47/48 ; A61K39/395 ; A61K45/00 ; C07D207/448 ; C07D207/452 ; A61P35/00 ; A61P37/02 ; A61P29/00
摘要：
A type of trimaleimide linkers and uses thereof are disclosed. The trimaleimide linkers can be applied for preparation of antibody-drug conjugate as shown by formula I: L-(T-A-D)nI wherein, L is an antibody, antibody fragment or protein; T is a trimaleimide linker; A is a cleavable linker group or a noncleavable linker; D is a drug; n is an integer ranging from 1 to 8.
公开/授权文献
- EP3302570B1 TRIMALEIMIDE LINKERS AND USES THEREOF 公开/授权日：2021-03-31
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