发明公开
- 专利标题： HUMAN PARAINFLUENZA TYPE 2 VIRUS VECTOR AND VACCINE
- 专利标题（中）： 人副流感病毒2型病毒载体和疫苗
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申请号： EP16807639.6申请日： 2016-06-13
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公开(公告)号： EP3309251A1公开(公告)日： 2018-04-18
- 发明人: NOSAKA, Tetsuya , TSURUDOME, Masato , FUKUMURA, Masayuki , OHTSUKA, Junpei , YUDA, Masao , IWANAGA, Shiroh
- 申请人： Mie University , BioComo Inc.
- 申请人地址： 1577, Kurimamachiya-cho Tsu-shi, Mie 514-8507 JP
- 专利权人： Mie University,BioComo Inc.
- 当前专利权人： Mie University,BioComo Inc.
- 当前专利权人地址： 1577, Kurimamachiya-cho Tsu-shi, Mie 514-8507 JP
- 代理机构： Keller, Günter
- 优先权： JP2015119097 20150612; JP2016063315 20160328
- 国际公布： WO2016199936 20161215
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K39/00 ; A61K39/015 ; A61K39/02 ; A61K39/04 ; A61K39/12 ; A61P31/04 ; A61P31/12 ; A61P35/00 ; C07K14/115
摘要：
The present invention relates to: a virus vector, which can effectively transfer a macromolecular antigenic peptide into target cells while maintaining a three-dimensional structure that is required for functioning as an antigen; and a vaccine utilizing the vector. Specifically, disclosed are: a virus vector, in which a nucleic acid encoding an antigenic polypeptide is integrated immediately 5' upstream of HN gene of an F gene-defective Paramyxoviridae virus gene, wherein the antigenic polypeptide is expressed as a fusion protein of 130 or more amino acid residues, fused with a TM sequence and/or a CT sequence derived from the virus.
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