- 专利标题： SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS
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申请号： EP16741825.0申请日： 2016-07-15
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公开(公告)号： EP3322706A1公开(公告)日： 2018-05-23
- 发明人: ANDREWS, Steven W. , BLAKE, James F. , CHICARELLI, Mark J. , GOLOS, Adam , HAAS, Julia , JIANG, Yutong , KOLAKOWSKI, Gabrielle R.
- 申请人： Array Biopharma, Inc.
- 申请人地址： 3200 Walnut Street Boulder, CO 80301 US
- 专利权人： Array Biopharma, Inc.
- 当前专利权人： Array Biopharma, Inc.
- 当前专利权人地址： 3200 Walnut Street Boulder, CO 80301 US
- 代理机构： Conroy, John
- 优先权： US201562193448P 20150716; US201562274018P 20151231
- 国际公布： WO2017011776 20170119
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; A61K31/437 ; A61P35/00 ; A61P29/00
摘要：
and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, D, E, X1, X2, X3 and X4 have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including diseases or disorders mediated by a RET kinase.
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