- 专利标题: SOLID PHARMACEUTICAL COMPOSITIONS FOR TREATING HCV
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申请号: EP16745584.9申请日: 2016-07-18
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公开(公告)号: EP3324941A1公开(公告)日: 2018-05-30
- 发明人: ASMUS, Katharin , GAO, Yi , GARRETT, Colleen , HACH, Harald , JAYASANKAR, Adivaraha , KYEREMATENG, Samuel , LANDER, Ute , MUELLER, Thomas , NARIS, Marius , OBERMILLER, Constanze , REUL, Regina , SCHNEIDER, Katrin , SEVER, Nancy , SIIMON, Michael , STEITZ, Benedikt , TONG, Ping , WESTEDT, Ulrich , ZHU, Donghua
- 申请人: AbbVie Inc.
- 申请人地址: 1 North Waukegan Road North Chicago, IL 60064 US
- 专利权人: AbbVie Inc.
- 当前专利权人: AbbVie Inc.
- 当前专利权人地址: 1 North Waukegan Road North Chicago, IL 60064 US
- 代理机构: Garner, Stephen
- 优先权: US201562193639P 20150717; US201662295309P 20160215; US201615192211 20160624
- 国际公布: WO2017015211 20170126
- 主分类号: A61K9/14
- IPC分类号: A61K9/14 ; A61K9/20 ; A61K9/24 ; A61K31/454 ; A61K31/498 ; A61P31/14
摘要:
The present invention features solid pharmaceutical compositions comprising Compound 1 and Compound 2. In one embodiment, the solid pharmaceutical composition includes (1) a first layer which comprises 100 mg Compound 1, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion; and (2) a second layer which comprises 40 mg Compound 2, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion.
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