发明公开
- 专利标题： MULTIMERIC IL-15 SOLUBLE FUSION MOLECULES AND METHODS OF MAKING AND USING SAME
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申请号： EP17200359.2申请日： 2011-09-21
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公开(公告)号： EP3327040A1公开(公告)日： 2018-05-30
- 发明人: WONG, Hing C. , RHODE, Peter , LIU, Bai , ZHU, Xiaoyun , HAN, Kai-ping
- 申请人： Altor BioScience Corporation
- 申请人地址： 2810 North Commerce Parkway Miramar, Florida 33025 US
- 专利权人： Altor BioScience Corporation
- 当前专利权人： Altor BioScience Corporation
- 当前专利权人地址： 2810 North Commerce Parkway Miramar, Florida 33025 US
- 代理机构： Hiebl, Inge Elisabeth
- 优先权： US384817P 20100921; US201161527911P 20110826
- 主分类号： C07K19/00
- IPC分类号： C07K19/00 ; C07K14/54 ; C07K14/075 ; C12N15/62 ; A61K38/17 ; A61P35/00 ; C12N1/00 ; C12N5/00 ; A61K38/00 ; C07K14/715 ; A61K38/20 ; C07K16/18 ; A61K45/06 ; C07K16/28 ; C12P21/00 ; C12N15/09
摘要：
The invention provides soluble fusion protein complexes having at least two soluble fusion proteins. The first fusion protein is a biologically active polypeptide covalently linked to an interleukin-15 (IL-15) polypeptide or a functional fragment thereof. The second fusion protein is a second biologically active polypeptide covalently linked to a soluble interleukin-15 receptor alpha (IL-15Rα) polypeptide or a functional fragment thereof. In the complexes of the invention, one or both of the first and second fusion proteins further includes an immunoglobulin Fc domain or a functional fragment thereof; and the first fusion protein binds to the soluble IL-15Rα domain of the second fusion protein to form a soluble fusion protein complex. The invention further provides methods for making and using the complexes of the invention.
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