- 专利标题： MEANS AND METHODS FOR INFLUENCING THE STABILITY OF ANTIBODY PRODUCING CELLS
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申请号： EP18150705.4申请日： 2006-12-08
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公开(公告)号： EP3327117A1公开(公告)日： 2018-05-30
- 发明人: Spits, Hergen , Scheeren, Ferenc Alexander , Beaumont, Tim , Diehl, Sean Andrew
- 申请人： Academisch Medisch Centrum bij de Universiteit van Amsterdam , AIMM Therapeutics B.V.
- 申请人地址： Meibergdreef 9 1105 AZ Amsterdam NL
- 专利权人： Academisch Medisch Centrum bij de Universiteit van Amsterdam,AIMM Therapeutics B.V.
- 当前专利权人： Academisch Medisch Centrum bij de Universiteit van Amsterdam,AIMM Therapeutics B.V.
- 当前专利权人地址： Meibergdreef 9 1105 AZ Amsterdam NL
- 代理机构： V.O.
- 优先权： PCT/NL2005/000848 20051209; EP06076211 20060612
- 主分类号： C12N5/0781
- IPC分类号： C12N5/0781 ; C12N5/10 ; C07K16/00 ; C12P21/08
摘要：
The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp-1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies using such cells and/or cell lines.
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