- 专利标题： ANTIGEN-BINDING PROTEINS TARGETING CD56 AND USES THEREOF
-
申请号： EP16833684.0申请日： 2016-08-01
-
公开(公告)号： EP3328994A1公开(公告)日： 2018-06-06
- 发明人: SADELAIN, Michel , BENJAMIN, Reuben , DIMITROV, Dimiter, S. , FENG, Yang
- 申请人： Memorial Sloan-Kettering Cancer Center , The United States of America, as represented by The Secretary, Department of Health and Human Services
- 申请人地址： 1275 York Avenue New York, NY 10065 US
- 专利权人： Memorial Sloan-Kettering Cancer Center,The United States of America, as represented by The Secretary, Department of Health and Human Services
- 当前专利权人： Memorial Sloan-Kettering Cancer Center,The United States of America, as represented by The Secretary, Department of Health and Human Services
- 当前专利权人地址： 1275 York Avenue New York, NY 10065 US
- 代理机构： Zacco Denmark A/S
- 优先权： US201562199775P 20150731
- 国际公布： WO2017023859 20170209
- 主分类号： C12N5/0783
- IPC分类号： C12N5/0783 ; C07K14/725 ; C07K16/30
摘要：
The presently disclosed subject matter provides for methods and compositions for treating cancer (e.g., multiple myeloma). It relates to anti-CD56 antibodies, chimeric antigen receptors (CARs) that specifically target human CD56, and immunoresponsive cells comprising such CARs. The presently disclosed CD56-specific CARs have enhanced immune-activating properties, including anti-tumor activity.
信息查询
