- 专利标题： DOSING REGIMEN OF ANTI-ALPHA4BETA7-ANTIKÖRPER
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申请号： EP18150968.8申请日： 2012-05-02
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公开(公告)号： EP3329965A3公开(公告)日： 2018-12-12
- 发明人: DILUZIO, Willow , TRUONG, Nobel T. , VARGA, Csanad M. , PALANIAPPAN, Vaithianathan , BROWN, Jason , FOX, Irving H. , SCHOLZ, Catherine
- 申请人： Millennium Pharmaceuticals, Inc.
- 申请人地址： 40 Landsdowne Street Cambridge, MA 02139 US
- 专利权人： Millennium Pharmaceuticals, Inc.
- 当前专利权人： Millennium Pharmaceuticals, Inc.
- 当前专利权人地址： 40 Landsdowne Street Cambridge, MA 02139 US
- 代理机构： Marshall, Cameron John
- 优先权： US201161481533P 20110502; US201161550545P 20111024; US201261585859P 20120112
- 主分类号： A61P1/00
- IPC分类号： A61P1/00 ; A61K39/395 ; C07K16/28 ; A61K9/00 ; A61K39/00 ; A61K9/19 ; A61K47/26 ; A61K47/18
摘要：
Antibody formulations are described comprising a mixture of a non-reducing sugar, an anti-α4β7 antibody and at least one amino acid. The disclosed formulations have improved stability, reduced aggregate formation, and may retard degradation of the anti-α4β7 antibody therein or exhibit any combinations thereof. The present invention further provides a safe dosing regimen of these antibody formulations that is easy to follow, and which results in a therapeutically effective amount of the anti-α4β7 antibody in vivo.
公开/授权文献
- EP3329965A1 DOSING REGIMEN OF ANTI-ALPHA4BETA7-ANTIBODIES 公开/授权日：2018-06-06
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