- 专利标题： VERFAHREN ZUR HERSTELLUNG DER METABOLITEN VON (4S) UND (4R)- 4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-2,8-DIMETHYL-1,4-DIHYDRO-1,6-NAPHTHYRIDIN-3-CARBOXAMID UND DEREN VERWENDUNG
- 专利标题（英）： EP3337799A1 - Method for the preparation of the metabolites of (4s)- and (4r)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide and the use thereof
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申请号： EP16750868.8申请日： 2016-08-15
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公开(公告)号： EP3337799A1公开(公告)日： 2018-06-27
- 发明人: PLATZEK, Johannes , ZORN, Ludwig
- 申请人： Bayer Pharma Aktiengesellschaft
- 申请人地址： Müllerstrasse 178 13353 Berlin DE
- 专利权人： Bayer Pharma Aktiengesellschaft
- 当前专利权人： Bayer Pharma Aktiengesellschaft
- 当前专利权人地址： Müllerstrasse 178 13353 Berlin DE
- 代理机构： BIP Patents
- 优先权： EP15182044 20150821
- 国际公布： WO2017032627 20170302
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; A61K31/437 ; A61P9/10
摘要：
The present invention relates to a novel method for the preparation of (4R)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula 4R (I) and the metabolites of (4S)- and (4R)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I), of the formulae M1a (S), M1b (R), M2a (S), M2b (R), M3a (S) and M3b (R) and the use thereof.
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