- 专利标题： BETA-ALANINE AMINOTRANSFERASES FOR THE PRODUCTION OF 3-HYDROXYPROPIONIC ACID
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申请号： EP16766417.6申请日： 2016-08-24
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公开(公告)号： EP3341475A1公开(公告)日： 2018-07-04
- 发明人: TASSONE, Monica , DIANO, Audrey
- 申请人： Novozymes A/S
- 申请人地址： Krogshoejvej 36 2880 Bagsvaerd DK
- 专利权人： Novozymes A/S
- 当前专利权人： Novozymes A/S
- 当前专利权人地址： Krogshoejvej 36 2880 Bagsvaerd DK
- 优先权： US201562209260P 20150824
- 国际公布： WO2017035270 20170302
- 主分类号： C12N9/10
- IPC分类号： C12N9/10 ; C12N1/16 ; C12P7/42
摘要：
Provided herein are recombinant host cells having an active 3-Hydroxypropionic Acid (3-HP) pathway wherein the host cells comprise a heterologous polynucleotide encoding an aminotransferase of E.C. 2.6.1.19 and wherein the aminotransferase comprises the motif (A,C)-Xn-(GSLS)-Xn-SKA(L/l)(L/l). Also described are methods of making the host cells, and methods using the cells to produce 3-HP and derivatives of 3-HP (e.g., acrylic acid).
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