- 专利标题: METHOD FOR PRODUCING AROMATIC COMPOUND AND DERIVATIVE THEREOF
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申请号: EP16839312.2申请日: 2016-08-24
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公开(公告)号: EP3342874A1公开(公告)日: 2018-07-04
- 发明人: NODA Shuhei , SHIRAI Tomokazu
- 申请人: RIKEN
- 申请人地址: 2-1, Hirosawa Wako-shi, Saitama 351-0198 JP
- 专利权人: RIKEN
- 当前专利权人: RIKEN
- 当前专利权人地址: 2-1, Hirosawa Wako-shi, Saitama 351-0198 JP
- 代理机构: J A Kemp
- 优先权: JP2015165023 20150824
- 国际公布: WO2017033965 20170302
- 主分类号: C12P7/22
- IPC分类号: C12P7/22 ; C12N1/15 ; C12N1/19 ; C12N1/21 ; C12P7/40 ; C12P7/42 ; C12P13/22 ; C12N15/09
摘要:
The present invention provides a method for producing an aromatic compound such as salicylic acid and a derivative thereof with high productivity using a microorganism. The present invention provides: a method for producing a microorganism having a sugar metabolic pathway modified, including suppressing the expression of a gene encoding a phosphotransferase system enzyme of the microorganism, suppressing the expression of a gene encoding pyruvate kinase of the microorganism, and introducing, into the microorganism, one or more genes encoding an enzyme that enables the microorganism to synthesize an aromatic compound from chorismic acid or isochorismic acid; a modified microorganism obtained by the method; and a method for producing an aromatic compound and a derivative thereof, including culturing the microorganism, and recovering an aromatic compound or the like from the culture.
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