- 专利标题： MANUFACTURING METHOD OF AN IMMUNOTHERAPEUTIC FORMULATION COMPRISING A RECOMBINANT LISTERIA STRAIN
-
申请号： EP16847136.5申请日： 2016-09-13
-
公开(公告)号： EP3350337A1公开(公告)日： 2018-07-25
- 发明人: WALLECHA, Anu , PATERSON, Yvonne
- 申请人： Advaxis, Inc. , The Trustees of the University of Pennsylvania
- 申请人地址： 305 College Road East Princeton, NJ 08540 US
- 专利权人： Advaxis, Inc.,The Trustees of the University of Pennsylvania
- 当前专利权人： Advaxis, Inc.,The Trustees of the University of Pennsylvania
- 当前专利权人地址： 305 College Road East Princeton, NJ 08540 US
- 代理机构： J A Kemp
- 优先权： US201562218884P 20150915
- 国际公布： WO2017048714 20170323
- 主分类号： C12P21/00
- IPC分类号： C12P21/00 ; C12N15/74 ; C07K14/005 ; C07K14/195 ; A61K38/16
摘要：
The present invention discloses a process for manufacturing a formulation comprising a drug substance, said drug substance comprising a recombinant Listeria comprising a human papilloma virus (HPV) antigen fused to a Listeriolysin O (LLO) protein fragment. The invention further discloses methods of using treating, protecting against, and inducing an immune response against cervical cancer comprising administration of the recombinant Listeria strain. The present invention also provides methods for inducing an anti-E7 CTL response in a human subject and treating HPV-mediated diseases, disorders, and symptoms, comprising administration of the recombinant Listeria strain.
信息查询
