- 专利标题： TREATMENT AND PREVENTION OF NEURONAL CELL LOSS USING L-ORNITHINE IN COMBINATION WITH AT LEAST ONE OF PHENYLACETATE AND PHENYLBUTYRATE
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申请号： EP16849626.3申请日： 2016-09-22
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公开(公告)号： EP3352748A1公开(公告)日： 2018-08-01
- 发明人: ROSE, Christopher, F. , CLÉMENT, Marc-André , BOSOI, Cristina, R. , OLIVEIRA, Mariana, Macedo , TREMBLAY, Mélanie , BÉMEUR, Chantal
- 申请人： Ocera Therapeutics, Inc.
- 申请人地址： 555 Twin Dolphin Drive, Suite 615 Redwood City, CA 94065 US
- 专利权人： Ocera Therapeutics, Inc.
- 当前专利权人： Ocera Therapeutics, Inc.
- 当前专利权人地址： 555 Twin Dolphin Drive, Suite 615 Redwood City, CA 94065 US
- 代理机构： J A Kemp
- 优先权： US201562233002P 20150925
- 国际公布： WO2017053613 20170330
- 主分类号： A61K31/198
- IPC分类号： A61K31/198 ; A61K31/192 ; A61K31/195 ; A61P25/00 ; A61P1/16
摘要：
Disclosed herein are methods of treating and preventing neuronal cell loss in a subject using ornithine in combination with phenylacetate or phenylbutyrate. In some embodiments, the subject has received or will receive a surgical procedure (for example, liver transplantation) for treating a liver disease. In some embodiments, the subject suffers from a liver disease and hypotension.
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