- 专利标题： PEPTIDE FOR INDUCING REGENERATION OF TISSUE AND USE THEREOF
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申请号： EP18160112.1申请日： 2012-04-03
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公开(公告)号： EP3358011A1公开(公告)日： 2018-08-08
- 发明人: TAMAI, Katsuto , YAMAZAKI, Takehiko , KANEZAKI, Tsutomu , SAKURAI, Shigeru , NOGUCHI, Yukiko , ENDO, Mayumi , HAMABUCHI, Natsumi , NAITO, Kana
- 申请人： Genomix Co., Ltd. , OSAKA UNIVERSITY
- 申请人地址： 3FL, Saito Biotechnology Incubator 7-15, Saito-Asagi 7-chome Ibaraki-shi Osaka 567-0085 JP
- 专利权人： Genomix Co., Ltd.,OSAKA UNIVERSITY
- 当前专利权人： Genomix Co., Ltd.,OSAKA UNIVERSITY
- 当前专利权人地址： 3FL, Saito Biotechnology Incubator 7-15, Saito-Asagi 7-chome Ibaraki-shi Osaka 567-0085 JP
- 代理机构： Zacco GmbH
- 优先权： JP2011098270 20110426; JP2011219454 20111003
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K31/711 ; A61K31/713 ; A61K35/12 ; A61K35/28 ; A61K35/76 ; A61K38/00 ; A61K48/00 ; A61P1/00 ; A61P1/04 ; A61P9/00 ; A61P9/10 ; A61P17/00 ; A61P19/00 ; A61P21/00 ; C07K14/47 ; C12N1/15 ; C12N1/19 ; C12N1/21 ; C12N5/10
摘要：
The present invention concerns therapeutic agents that, in association with stimulation of PDGFRα-positive cells such as bone marrow mesenchymal stem cells, promote their mobilization into blood and accumulation in a damaged tissue, and induce tissue regeneration in a living body. In particular, fragments of High mobility Group Box 1 (HMGB1 or amphoterin) which stimulate PDGFRalpha-positive cells and promote their mobilization into blood and accumulation in a damaged tissue. Peptide fragments of HMGB1 were identified with migration-promoting activity on PDGFR-alpha-positive bone marrow mesenchymal stem cell line (MSC-1) and skin fibroblasts.
公开/授权文献
- EP3358011B1 PEPTIDE FOR INDUCING REGENERATION OF TISSUE AND USE THEREOF 公开/授权日：2020-03-04
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