- 专利标题： IDENTIFICATION OF CD8+ T CELLS THAT ARE CD161HI AND/OR IL18RALPHAHI AND HAVE RAPID DRUG EFFLUX CAPACITY
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申请号： EP17209395.7申请日： 2009-01-28
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公开(公告)号： EP3363893A1公开(公告)日： 2018-08-22
- 发明人: TURTLE, Cameron, J. , RIDDELL, Stanley, R.
- 申请人： Fred Hutchinson Cancer Research Center
- 申请人地址： 1100 Fairview Avenue N. M/S J6-200 Seattle, WA 98109-1024 US
- 专利权人： Fred Hutchinson Cancer Research Center
- 当前专利权人： Fred Hutchinson Cancer Research Center
- 当前专利权人地址： 1100 Fairview Avenue N. M/S J6-200 Seattle, WA 98109-1024 US
- 代理机构： Tollervey, Rebecca Marie
- 优先权： US24241P 20080129
- 主分类号： C12N5/0783
- IPC分类号： C12N5/0783 ; A61K48/00 ; G01N33/50 ; A61K35/26 ; A61K35/17 ; A61K39/00
摘要：
This invention provides, among other things, methods for the identification and isolation of viable putative long-lived antigen-specific memory CD8 + T cell subsets (CMhi and EMhi) with high surface expression of CD161 and/or IL-18Ra and the capacity to rapidly efflux the fluorescent dye Rh123.
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