An optical amplification system includes: three or more nodes; a multi-core fiber having a plurality of cores, the multi-core fiber being used in at least a partial segment of the connection between the nodes; an amplification light input unit configured to input amplification light to a core of the plurality of cores of the multi-core fiber; an amplification unit configured to amplify communication light transmitted through at least one core of the plurality of cores of the multi-core fiber using the amplification light, the amplification unit being provided in the nodes or between the nodes; and an amplification light coupling unit configured to couple the amplification light input by the amplification light input unit to the amplification unit.