- 专利标题： METHODS FOR PRODUCING HEPATOCYTES
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申请号： EP16801292.0申请日： 2016-10-29
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公开(公告)号： EP3368657A1公开(公告)日： 2018-09-05
- 发明人: HAGBARD, Louise, Kristina , ERICCSON, Carl, Gunnar Jesper , CAMERON, Katherine, Rachel , HAY, David, Colin , FORBES, Stuart, John , RASHIDI, Hassan
- 申请人： Biolamina AB , The University of Edinburgh
- 申请人地址： Lofstroms Alle 5 Sundbyberg 17266 Stockholm SE
- 专利权人： Biolamina AB,The University of Edinburgh
- 当前专利权人： Biolamina AB,The University of Edinburgh
- 当前专利权人地址： Lofstroms Alle 5 Sundbyberg 17266 Stockholm SE
- 代理机构： Kador & Partner PartG mbB
- 优先权： US201562248389P 20151030
- 国际公布： WO2017072580 20170504
- 主分类号： C12N5/071
- IPC分类号： C12N5/071
摘要：
Methods for producing hepatocytes from pluripotent human stem cells are disclosed herein. The stem cells are plated on a cell culture substrate comprising two laminins. The stem cells are then exposed to different cell culture mediums to induce differentiation. The resulting hepatocytes have higher metabolic capacity compared to hepatocytes cultured on different substrates.
公开/授权文献
- EP3368657B1 METHODS FOR PRODUCING HEPATOCYTES 公开/授权日：2021-06-30
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