- 专利标题： HUMANIZED M-CSF MICE AND USES THEREOF
-
申请号： EP18166409.5申请日： 2012-02-14
-
公开(公告)号： EP3375284A1公开(公告)日： 2018-09-19
- 发明人: MURPHY, Andrew J. , STEVENS, Sean , RATHINAM, Chozhavendan , EYNON, Elizabeth , MANZ, Markus G. , FLAVELL, Richard , YANCOPOULOS, George D.
- 申请人： Regeneron Pharmaceuticals, Inc. , Yale University, Inc. , Institute for Research in Biomedicine (IRB)
- 申请人地址： 777 Old Saw Mill River Road Tarrytown, NY 10591-6707 US
- 专利权人： Regeneron Pharmaceuticals, Inc.,Yale University, Inc.,Institute for Research in Biomedicine (IRB)
- 当前专利权人： Regeneron Pharmaceuticals, Inc.,Yale University, Inc.,Institute for Research in Biomedicine (IRB)
- 当前专利权人地址： 777 Old Saw Mill River Road Tarrytown, NY 10591-6707 US
- 代理机构： Hayes, Emily Anne Luxford
- 优先权： US201161442946P 20110215
- 主分类号： A01K67/027
- IPC分类号： A01K67/027
摘要：
Genetically modified mice comprising a nucleic acid sequence encoding a human M-CSF protein are provided. Also provided are genetically modified mice comprising a nucleic acid sequence encoding a human M-CSF protein that have been engrafted with human cells such as human hematopoietic cells, and methods for making such engrafted mice. These mice find use in a number of applications, such as in modeling human immune disease and pathogen infection; in in vivo screens for agents that modulate hematopoietic cell development and/or activity, e.g. in a healthy or a diseased state; in in vivo screens for agents that are toxic to hematopoietic cells; in in vivo screens for agents that prevent against, mitigate, or reverse the toxic effects of toxic agents on hematopoietic cells; in in vivo screens of human hematopoietic cells from an individual to predict the responsiveness of an individual to a disease therapy, etc.
公开/授权文献
- EP3375284B1 HUMANIZED M-CSF MICE AND USES THEREOF 公开/授权日：2023-03-29
信息查询
